Recent clinical trials have revealed promising results regarding weight loss medications, specifically Zepbound and Wegovy. According to Eli Lilly, Zepbound has been shown to be more effective for long-term weight loss compared to Wegovy.
In the SURMOUNT-5 clinical trial, 20% of those receiving Zepbound achieved significant weight loss, while only 14% of Wegovy participants experienced similar results. Moreover, 31% of individuals taking Zepbound managed to lose at least 25% of their body weight, compared to 16% for those taking Wegovy.
On average, participants in the Zepbound group lost approximately 50 pounds, whereas those using Wegovy lost about 33 pounds. The trial included 751 participants from the United States and Puerto Rico, all of whom were either overweight or had obesity along with at least one comorbidity, such as hypertension or sleep apnea.
It is essential to note that the effectiveness of any weight loss medication is significantly enhanced by a commitment to a healthy diet and regular physical activity. Experts stress that these medications are not a quick fix but rather a part of a comprehensive lifestyle approach.
Dr. Mir Ali, a bariatric surgeon, mentioned that Zepbound affects two hormone receptors, enhancing satiety and slowing digestion, which contributes to its efficacy over Wegovy, which primarily interacts with one receptor.
Access to these medications can be problematic, with issues surrounding insurance coverage and supply shortages being prevalent. However, both physicians and patients agree that utilizing either Zepbound or Wegovy can represent a substantial step forward in managing and reducing obesity.
Ultimately, while Zepbound shows more potential for long-term weight loss, the journey requires a dedication to healthier living. Understanding the necessity of maintaining therapy and the possible need for lifelong commitment is crucial for those considering weight loss medications.
For more in-depth insight about these medications, including potential risks and benefits, consult with your healthcare provider.
Source: Healthline
